Health officials announced the national vaccine deaths total on Thursday, showing the virus killed 6,636 people in the United States in the last week of the month.
The numbers were the second-lowest in five months and the largest in nearly five years.
The death toll for the last six weeks of 2018 was 5,928, the Centers for Disease Control and Prevention said.
The latest figures show that of the 6,000 people who died in November and December, 1,854 died in 2017, the first year for which national data is available.
The CDC said more than 1,400 people died from other causes in the country.
On Thursday, the CDC also announced the vaccine is not recommended for people under 18, and the number of people with COVID-19 symptoms is increasing.
CDC: More than half of people infected with COV-19 live in states that have not yet declared a state of emergency.
The death toll in the U.S. for COVID is expected to continue to climb, even as the virus is spreading.